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Nathalia Glickman Holtzman
Position: Associate Professor and Chair, Biology
Campus Affiliation: Graduate Center|Queens College
Phone: (718) 997-3678
Degrees/Diplomas: Ph.D. in Biology
Subprogram: Molecular, Cellular, and Developmental Biology
Research Interests: Dr. Holtzman’s interests includes cardiovascular development and the impact of environmental toxins on embryonic development, as well as educational research includes cardiovascular development and the impact of environmental toxins on embryonic development, as well as educational research.
Research Focus: Cancer/Cell Division and Death|Cell Structure, Interactions, Organelles and Metabolism|Genetics/Development

Science Publications

  • 2020Singleman, CP., A. ZimmermanU, E.HarrisonH, N. Roy, I. Wirgin and N. G. Holtzman “Toxic effects of PCB confiners and Aroclors on embryonic growth and development.” Oct 29:Environmental Toxicology and Chemistry DOI:10.1002/etc.4908
  • 2016 Pavel, M.AP., C. Lv, C. Ng, L. Yang, P. Kashyap, C. Lam, V. Valentino, H. Fung, T. Campbell, S.G. Moller, D. Zenisek, N. G. Holtzman and Y. Yu. “Function and regulation of TRPP2 ion channel revealed by a gain-of-function mutation.” PNAS (Apr 26;113(17)):E2363-72. doi.org/10.1073/pnas.1517066113
  • 2016Holtzman, N.G., M.K. Iovine, J.O. Liang, and J. Morris. “Learning to fish with genetics: a primer on the vertebrate model Danio rerio.” Genetics. Jul;203(3):1069-89.(Invited Review) doi: 10.1534/genetics.116.190843.
  • 2016Prabhudesai SP, Bensabeur FZ, Abdullah R, Basak I, Baez S, Alves G, Holtzman N.G., Larsen JP, Møller SG. “LRRK2 knockdown in zebrafish causes developmental defects, neuronal loss, and synuclein aggregation.” J Neurosci Res. Aug;94(8):717-35. doi: 10.1002/jnr.23754
  • 2014Singleman, C.P and N. G. Holtzman. “Growth and Maturation in the Zebrafish, Danio rerio: A Staging Tool for Teaching and Research.” Zebrafish, Aug; 11(4):396-406. DOI: 10.1089/zeb.2014.0976
  • 2013 Lenhart, K.F.P, N. G. Holtzman, Williams, J.RP. and R. D. Burdine. “Integration of Nodal and BMP Signals in the Heart Requires FoxH1 to Create Left-Right Differences in Cell Migration Rates That Direct Cardiac Asymmetry.” PLoS Genetics, Jan;9(1):e1003109. doi.org/10.1371/journal.pgen.1003109
  • 2012Singleman, C.P and N. G. Holtzman. “Analysis of Post-Embryonic Heart Development and Maturation in the Zebrafish, Danio rerio.” Developmental Dynamics, 241(12):1993-2004. doi: 10.1002/dvdy.23882
  • 2011Singleman, C.P and N.G. Holtzman. “Heart Dissection in Larval, Juvenile and Adult Zebrafish, Danio rerio,” J Vis Exp.Sep 30;(55): e3165. doi: 10.3791/3165.
  • 2008 Baker, K.P, N.G. Holtzman, and R.D. Burdine. “Direct and indirect roles for Nodal signaling in two axis conversions during asymmetric morphogenesis of the zebrafish heart.” PNAS, 105(37): 13924-9. doi.org/10.1073/pnas.0802159105
  • 2008Osborne, N.P,  K. Brand-Arzamendi, E.A. Ober, S.W. Jin, H. Verkade, N G. Holtzman, D. Yelon and Didier Y.R. Stainier. “The Spinster Homolog, Two of Hearts, Is Required for Sphingosine 1-Phosphate Signaling in Zebrafish.” Current Biology, 18: 1882-1888. https://doi.org/10.1016/j.cub.2008.10.061
  • 2008 de Campos-Baptista , M.I.P, N.G. Holtzman, D. Yelon, and A.F. Schier. “Nodal Signaling Promotes the Speed and Directional Movement of Cardiomyocytes in Zebrafish.” Dev Dyn. 237(12): 3624 – 3633. doi: 10.1002/dvdy.21777
  • 2007 Glickman Holtzman, N., J. SchoenebeckP , H.J. Tsai, and D. Yelon. “Region Specific Cell Movements Direct Heart Tube Assembly in Zebrafish.” Development, 134: 2379-2386 doi: 10.1242/dev.02857.
  • 2004Glickman, N.S. and D. Yelon. “Coordinating morphogenesis: epithelial integrity during heart tube assembly.” Dev Cell. Mar;6(3):311-2. (Invited Review) DOI: 10.1016/s1534-5807(04)00070-x
  • 2002Glickman, N.S. and D. Yelon.“Cardiac development in zebrafish: coordination of form and function.” Semin Cell Dev Biol. Dec;13(6):507-13. (Invited Review)  DOI: 10.1016/s1084952102001040
  • 2003Glickman, N.S., C.B. Kimmel, M. JonesU, C. Walker, and R.J. Adams. “Shaping the Zebrafish Notochord.” Development, 130(5): 873-87. doi: 10.1242/dev.00314
  • 1996Larsen, E., T. Lee, and N.S. Glickman. “Antenna to Leg Transformation: Dynamics of Developmental Competence.” Developmental Genetics, 19(4): 333-339.  https://doi.org/10.1002/(SICI)1520-6408(1996)19:4<333::AID-DVG6>3.0.CO;2-A

Education Publications

Courses Taught

  • BIOL 105/108: General Biology: Physiology and Cell Biology
  • HNRS 225: Science Technology and New York City
  • BIOL 750: Developmental Biology
  • BIOL 200 Introduction to research
  • BIOL 286/586 Cell Biology
  • BIOL 13 Writing in the sciences
  • BICM71020 Advanced Biochemistry 2
  • BICM 72020 Basic Seminar in Advanced Biochemistry
  • Biol 700: Genetics, team taught with Dr. Rudner and Dr. Chung
  • Embryology Course
  • Marine Biological Laboratories at Woods Hole